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KMID : 0605720110170020229
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Journal of the Korean Society of Biological Therapies in Psychiatry
2011 Volume.17 No. 2 p.229 ~ p.238
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Body Weight and Metabolic Changes in First-Episode Psychotic Patients with Antipsychotics Use : A Retrospective Study
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Kim Woo-Jin
Shim Joo-Cheol
Kong Bo-Geum
Kang Je-Wook
Moon Jung-Joon
Kim Jeong-Eun
Kim Min-Geol
Park Min-Kyeong
Kim Sung-Jin
Kim Hyun-Jung
Jung Do-Un
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Abstract
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Objectives: This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use.
Method: In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain.
Results: First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain.
Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.
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KEYWORD
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Antispychotics, First-episode psychosis, Body weight, Body mass index(BMI)
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